Analysis of similarity/dissimilarity of DNA sequences based on adjacent nucleotide pair representation

Introduction of graphic representation for nucleotide or protein sequences can provide intuitive overall pictures as well as useful insights for performing large-scale similarity analysis. In this paper, we are analyzing the similarity/dissimilarity of the mitochondrial genome sequences from twenty four mammal species. The analysis is important in finding the relatedness among the species and eventually finding the evolutionary relationship. The evolutionary tree or phylogenetic tree is constructed by Unweighted Pair Group Method with Arithmetic Mean (UPGMA). The graphical representation of DNA sequence using Adjacent Nucleotide Pair has been constructed. The distance matrix required for the construction of phylogenetic tree has been built by applying the biological geometry method. Keywords—Graphical representation; similarity analysis; sequence comparison